Functional resting-state brain connectivity is accompanied by dynamic correlations of application-dependent [¹⁸F]FDG PET-tracer fluctuations.

ABSTRACT: Brain function is characterized by a convolution of various biochemical and physiological processes, raising the interest whether resting-state functional connectivity derived from hemodynamic scales shows underlying metabolic synchronies. Increasing evidence suggests that metabolic connectivity based on glucose consumption associated PET recordings may serve as a marker of cognitive functions and neuropathologies. However, to what extent fMRI-derived resting-state brain connectivity can also be characterized based on dynamic fluctuations of glucose metabolism and how metabolic connectivity is influenced by [¹⁸F]FDG pharmacokinetics remains unsolved. Simultaneous PET/MRI measurements were performed in a total of 26 healthy male Lewis rats. Simultaneously to resting-state fMRI sc

SUBMITTER: Amend M 

PROVIDER: S-EPMC10673660 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature