The Landscape of BRCA Mutations among Egyptian Women with Breast Cancer.

ABSTRACT:

Background

Deleterious germline mutations in BRCA1 and BRCA2 genes are associated with a high risk of breast and ovarian cancer. In many developing countries, including Egypt, the prevalence of BRCA1/2 mutations among women with breast cancer (BC) is unknown.

Aim

We aimed to determine the prevalence of deleterious germline BRCA mutations in Egyptian patients with breast cancer.

Methods

We report the results of a cohort study of 81 Egyptian patients with breast cancer who were tested for germline BRCA1/2 mutations during routine clinical practice, mostly for their young age of presentation, BC subtype, or presence of family history. In addition, we searched five databases to retrieve studies that reported the prevalence of BRCA1/2 mutation status in Egyptian women with

SUBMITTER: Azim HA 

PROVIDER: S-EPMC10673778 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature