Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature.

ABSTRACT:

Background

Gastric cancer (GC) is a heterogeneous malignancy with variable clinical outcomes. The immune system has been implicated in GC development and progression, highlighting the importance of immune-related gene expression patterns and their prognostic significance.

Objective

This study aimed to identify differentially expressed immune-related genes (DEIRGs) and establish a prognostic index for GC patients using comprehensive bioinformatic analyses.

Methods

We integrated RNA sequencing data from multiple databases and identified DEIRGs by overlapping differentially expressed genes with immune-related genes. Functional enrichment analysis was performed to uncover the biological processes and signaling pathways associated with DEIRGs. We conducted a Weighted Gene

SUBMITTER: Meng X 

PROVIDER: S-EPMC10673795 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature