A Comparative Evaluation of the Measurement Properties of Three Histological Indices of Mucosal Healing in Ulcerative Colitis: Geboes Score, Robarts Histopathology Index and Nancy Index.

ABSTRACT:

Background and aims

To inform their future use in regulated clinical trials to evaluate treatment efficacy hypotheses, the measurement properties of three histological indices, Geboes Score [GS], Robarts Histopathology Index [RHI] and Nancy Index [NI], were evaluated among patients with ulcerative colitis.

Methods

Analyses were conducted on data from a Phase 3 clinical trial of adalimumab [M14-033, n = 491] and focused on evaluating the measurement properties of the GS, RHI and NI. Specifically, internal consistency and inter-rater reliability, convergent, discriminant and known-group validity, and sensitivity to change were assessed at Baseline, and at Weeks 8 and 52.

Results

Internal consistency for the RHI showed lower alpha [α] values at Baseline [α = 0.62] relati

SUBMITTER: Peyrin-Biroulet L 

PROVIDER: S-EPMC10673803 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature