Cytolytic circumsporozoite-specific memory CD4⁺ T cell clones are expanded during Plasmodium falciparum infection.

ABSTRACT: Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms during infection and in protection against severe disease but the mechanisms are not fully understood. Here, we compare the cellular and humoral immune response of clinically immune (0-1 episode over 18 months) and susceptible (at least 3 episodes) during a mild episode of Pf malaria infection in a malaria endemic region of Malawi, by analysing peripheral blood samples using high dimensional mass cytometry (CyTOF), spectral flow cytometry and single-cell transcriptomic analyses. In the clinically immune, we find increased proportions of circulating follicular helper T cells and classical monocytes, while the humoral immune response shows chara

SUBMITTER: Furtado R 

PROVIDER: S-EPMC10673885 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature