Identification of peptides from honeybee gut symbionts as potential antimicrobial agents against Melissococcus plutonius.

ABSTRACT: Eusocial pollinators are crucial elements in global agriculture. The honeybees and bumblebees are associated with a simple yet host-restricted gut community, which protect the hosts against pathogen infections. Recent genome mining has led to the discovery of biosynthesis pathways of bioactive natural products mediating microbe-microbe interactions from the gut microbiota. Here, we investigate the diversity of biosynthetic gene clusters in the bee gut microbiota by analyzing 477 genomes from cultivated bacteria and metagenome-assembled genomes. We identify 744 biosynthetic gene clusters (BGCs) covering multiple chemical classes. While gene clusters for the post-translationally modified peptides are widely distributed in the bee guts, the distribution of the BGC classes varies significantly

SUBMITTER: Lang H 

PROVIDER: S-EPMC10673953 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature