Cu-mediated enantioselective C-H alkynylation of ferrocenes with chiral BINOL ligands.

ABSTRACT: A wide range of Cu(II)-catalyzed C-H activation reactions have been realized since 2006, however, whether a C-H metalation mechanism similar to Pd(II)-catalyzed C-H activation reaction is operating remains an open question. To address this question and ultimately develop ligand accelerated Cu(II)-catalyzed C-H activation reactions, realizing the enantioselective version and investigating the mechanism is critically important. With a modified chiral BINOL ligand, we report the first example of Cu-mediated enantioselective C-H activation reaction for the construction of planar chiral ferrocenes with high yields and stereoinduction. The key to the success of this reaction is the discovery of a ligand acceleration effect with the BINOL-based diol ligand in the directed Cu-catalyzed C-H alkynyl

SUBMITTER: Kuang X 

PROVIDER: S-EPMC10673954 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature