Efficacy and safety of isotonic versus hypotonic intravenous maintenance fluids in hospitalized children: an updated systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Iatrogenic hyponatremia is a common complication following intravenous maintenance fluid therapy (IV-MFT) in hospitalized children. Despite the American Academy of Pediatrics' 2018 recommendations, IV-MFT prescribing practices still vary considerably.

Objectives

This meta-analysis aimed to compare the safety and efficacy of isotonic versus hypotonic IV-MFT in hospitalized children.

Data sources

We searched PubMed, Scopus, Web of Science, and Cochrane Central from inception to October 1, 2022.

Study eligibility criteria

We included randomized controlled trials (RCTs) comparing isotonic versus hypotonic IV-MFT in hospitalized children, either with medical or surgical conditions. Our primary outcome was hyponatremia following IV-MFT. Secondary outcomes

SUBMITTER: Amer BE 

PROVIDER: S-EPMC10673968 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature