Diaphragmatic hernia repair porcine model to compare the performance of biodegradable membranes against Gore-Tex^®.

ABSTRACT:

Background

Patch repair of congenital diaphragmatic hernia (CDH) using Gore-Tex^® is associated with infection, adhesions, hernia recurrence, long-term musculoskeletal sequels and poor tissue regeneration. To overcome these limitations, the performance of two novel biodegradable membranes was tested to repair CDH in a growing pig model.

Methods

Twelve male pigs were randomly assigned to 3 different groups of 4 animals each, determined by the type of patch used during thoracoscopic diaphragmatic hernia repair (Gore-Tex^®, polycaprolactone electrospun membrane-PCLem, and decellularized human chorion membrane-dHCM). After 7 weeks, all animals were euthanized, followed by necropsy for diaphragmatic evaluation and histological analysis.

Results

Thoracos

SUBMITTER: Scuglia M 

PROVIDER: S-EPMC10673990 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature