Quantifying variation in home spirometry in people with cystic fibrosis during baseline health, and associations with clinical outcomes.

ABSTRACT:

Background

Home spirometry is increasingly used to monitor lung function in people with cystic fibrosis (pwCF). Although decreases in lung function in the setting of increased respiratory symptoms are consistent with a pulmonary exacerbation (PEx), the interpretation of home spirometry during asymptomatic periods of baseline health is unclear. The aims of this study were to determine the variation in home spirometry in pwCF during asymptomatic periods of baseline health and to identify associations between this variation and PEx.

Methods

Near-daily home spirometry measurements were obtained from a cohort of pwCF enrolled in a long-term study of the airway microbiome. Associations between the degree of variation in home spirometry and the time to next PEx were evaluated.

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SUBMITTER: Thornton CS 

PROVIDER: S-EPMC10674030 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature