Longitudinal Patterns of Brain Changes in a Community Sample in Relation to Aging and Cognitive Status.

ABSTRACT:

Background

Aging and Alzheimer's disease (AD) are characterized by widespread cortical and subcortical atrophy. Though atrophy patterns between aging and AD overlap considerably, regional differences between these two conditions may exist. Few studies, however, have investigated these patterns in large community samples.

Objective

Elaborate longitudinal changes in brain morphometry in relation to aging and cognitive status in a well-characterized community cohort.

Methods

Clinical and neuroimaging data were compiled from 72 participants from the Cardiovascular Health Study-Cognition Study, a community cohort of healthy aging and probable AD participants. Two time points were identified for each participant with a mean follow-up time of 5.36 years. MRI post-processing,

SUBMITTER: Chwa WJ 

PROVIDER: S-EPMC10674101 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature