External Evaluation of Population Pharmacokinetics Models of Lithium in the Bipolar Population.

ABSTRACT: Lithium has been used in the treatment of bipolar disorder for several decades. Treatment optimization is recommended for this drug, due to its narrow therapeutic range and a large pharmacokinetics (PK) variability. In addition to therapeutic drug monitoring, attempts have been made to predict individual lithium doses using population pharmacokinetics (popPK) models. This study aims to assess the clinical applicability of published lithium popPK models by testing their predictive performance on two different external datasets. Available PopPK models were identified and their predictive performance was determined using a clinical dataset (46 patients/samples) and the literature dataset (89 patients/samples). The median prediction error (PE) and median absolute PE were used to assess bias an

SUBMITTER: Aurelie L 

PROVIDER: S-EPMC10674621 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature