Ontology highlight
ABSTRACT:
SUBMITTER: Mghezzi-Habellah M
PROVIDER: S-EPMC10674744 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Mghezzi-Habellah Makram M Prochasson Léa L Jalinot Pierre P Mocquet Vincent V
Viruses 20231106 11
In eukaryotic cells, the spatial distribution between cytoplasm and nucleus is essential for cell homeostasis. This dynamic distribution is selectively regulated by the nuclear pore complex (NPC), which allows the passive or energy-dependent transport of proteins between these two compartments. Viruses possess many strategies to hijack nucleocytoplasmic shuttling for the benefit of their viral replication. Here, we review how viruses interfere with the karyopherin CRM1 that controls the nuclear ...[more]