The Role of GeneXpert^® for Tuberculosis Diagnostics in Brazil: An Examination from a Historical and Epidemiological Perspective.

ABSTRACT: The rapid molecular test (RMT) performed on the GeneXpert^® system is widely used as a control strategy and surveillance technique for tuberculosis (TB). In the region of the Americas, TB incidence is slowly increasing owing to an upward trend in Brazil, which is among the high TB-burden countries (HBCs), ranking in the 19th position. In this context, we aimed to (i) describe the implementation and history of RMT-TB (Xpert^® MTB/RIF and Xpert^® MTB/RIF Ultra) in Brazil; (ii) to evaluate the national RMT laboratory distribution, TB, and resistance to RIF detection by RMT; and (iii) to correlate these data with Brazilian TB incidence. The quantitative data of Xpert^® MTB/RIF and Xpert^® MTB/RIF Ultra assays performed in the pulmonary TB inves

SUBMITTER: Iudice TNDS 

PROVIDER: S-EPMC10674801 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature