In Vivo Evaluation of a Gastro-Resistant Enprotect^® Capsule under Postprandial Conditions.

ABSTRACT: Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel^® Enprotect^® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but robustness against postprandial intake needed to be proven. In this study, the capsules were administered to 16 healthy young subjects after intake of a light meal. The Enprotect^® capsules were labelled with 5 mg black iron oxide and 25 mg ¹³C₃-caffeine. Magnetic Resonance Imaging was used to identify the localization and visual dispersion of the capsule filling. The salivary appearance of caffeine was considered a second independent and sensitive marker for the initial release. Whereas the fasted gast

SUBMITTER: Grimm M 

PROVIDER: S-EPMC10674880 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature