Bimetal-Organic Framework-Loaded PVA/Chitosan Composite Hydrogel with Interfacial Antibacterial and Adhesive Hemostatic Features for Wound Dressings.

ABSTRACT: Silver-containing wound dressings have shown attractive advantages in the treatment of wound infection due to their excellent antibacterial activity. However, the introduction of silver ions or AgNPs directly into the wound can cause deposition in the body as particles. Here, with the aim of designing low-silver wound dressings, a bimetallic-MOF antibacterial material called AgCu@MOF was developed using 3, 5-pyridine dicarboxylic acid as the ligand and Ag⁺ and Cu²⁺ as metal ion sites. PCbM (PVA/chitosan/AgCu@MOF) hydrogel was successfully constructed in PVA/chitosan wound dressing loaded with AgCu@MOF. The active sites on the surface of AgCu@MOF increased the lipophilicity to bacteria and caused the bacterial membrane to undergo lipid peroxidation, which resulted in t

SUBMITTER: Zhang N 

PROVIDER: S-EPMC10674882 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature