Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer.

ABSTRACT: Prostate cancer (PC) is the most diagnosed tumor in males and ranks as the second leading cause of male mortality in the western world. The CD39 and CD73 enzymes play a crucial role in cancer regulation by degrading nucleotides and forming nucleosides. This study aimed to investigate the expression of the CD39 and CD73 enzymes as potential therapeutic targets for PC. The initial part of this study retrospectively analyzed tissue samples from 23 PC patients. Using the TissueFAXS^TM cytometry platform, we found significantly higher levels of CD39-labeling its intensity compared to CD73. Additionally, we observed a correlation between the Gleason score and the intensity of CD39 expression. In the prospective arm, blood samples were collected from 25 patients at the time of diagnosis

SUBMITTER: Gardani CFF 

PROVIDER: S-EPMC10675019 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature