Characterization of Fusarium verticillioides Med1 LxxLL Motif Involved in Fumonisin Biosynthesis.

ABSTRACT: The Med1 transcriptional coactivator is a crucial component of the Mediator middle complex, which regulates the expression of specific genes involved in cell development, differentiation, reproduction, and homeostasis. The Med1 LxxLL motif, a five-amino-acid peptide sequence, is essential for Med1-mediated gene expression. Our previous study revealed that the disruption of the Med1 subunit leads to a significant increase in fumonisin B₁ (FB₁) production in the maize pathogen Fusarium verticillioides. However, our understanding of how Med1 regulates FB₁ biosynthesis in F. verticillioides, particularly through the Med1 LxxLL motifs, remains limited. To characterize the role of LxxLL motifs, we generated a series of Med1 LxxLL deletion and amino

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10675092 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature