Preliminary Insights of Brazilian Snake Venom Metalloproteomics.

ABSTRACT: Snakebite envenoming is one of the most significantly neglected tropical diseases in the world. The lack of diagnosis/prognosis methods for snakebite is one of our motivations to develop innovative technological solutions for Brazilian health. The objective of this work was to evaluate the protein and metallic ion composition of Crotalus durissus terrificus, Bothrops jararaca, B. alternatus, B. jararacussu, B. moojeni, B. pauloensis, and Lachesis muta muta snake venoms. Brazilian snake venoms were subjected to the shotgun proteomic approach using mass spectrometry, and metal ion analysis was performed by atomic spectrometry. Shotgun proteomics has shown three abundant toxin classes (PLA₂, serine proteases, and metalloproteinases)

SUBMITTER: Cavecci-Mendonca B 

PROVIDER: S-EPMC10675094 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature