Lamivudine and Entecavir for Acute Hepatitis B: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Acute hepatitis B infection is associated with severe liver disease and chronic sequelae in some cases. The purpose of this review was to determine the efficacy of nucleoside analogues (NA) (lamivudine versus entecavir) compared to placebo or no intervention for treating acute primary HBV infection.

Methods

A meta-analysis for drug intervention was performed, following a fixed-effect model. Randomized controlled trials (RCTs) and quasi-randomized studies that evaluated the outcomes of NA in acute hepatitis B infection were included. The following outcomes were considered: virological cure (PCR negative), elimination of acute infection (seroconversion of HBsAg), mortality, and serious adverse events.

Results

Five trials with 627 adult participants with sever

SUBMITTER: Henriquez-Camacho C 

PROVIDER: S-EPMC10675181 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature