Novel Immunotherapies and Combinations: The Future Landscape of Multiple Myeloma Treatment.

ABSTRACT: In multiple myeloma impressive outcomes have improved with the introduction of new therapeutic approaches, mainly those including naked monoclonal antibodies such as daratumumab and isatuximab. However, moving to earlier lines of therapy with effective anti-myeloma drugs led to an increase in the number of patients who developed multi-refractoriness to them early on. Currently, triple- or multi-refractory MM represents an unmet medical need, and their management remains a complicated challenge. The recent approval of new immunotherapeutic approaches such as conjugated monoclonal antibodies, bispecific antibodies, and CAR T cells could be a turning point for these heavily pretreated patients. Nevertheless, several issues regarding their use are unsolved, such as how to select patients for e

SUBMITTER: More S 

PROVIDER: S-EPMC10675193 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature