Comparative Immune Response after Vaccination with SOBERANA^® 02 and SOBERANA^® plus Heterologous Scheme and Natural Infection in Young Children.

ABSTRACT: (1) Background: In children, SARS-CoV-2 infection is mostly accompanied by mild COVID-19 symptoms. However, multisystem inflammatory syndrome (MIS-C) and long-term sequelae are often severe complications. Therefore, the protection of the pediatric population against SARS-CoV-2 with effective vaccines is particularly important. Here, we compare the humoral and cellular immune responses elicited in children (n = 15, aged 5-11 years) vaccinated with the RBD-based vaccines SOBERANA^® 02 and SOBERANA^® Plus combined in a heterologous scheme with those from children (n = 10, aged 4-11 years) who recovered from mild symptomatic COVID-19. (2) Methods: Blood samples were taken 14 days after the last dose for vaccinated children and 45-60 days after the infection di

SUBMITTER: Perez-Nicado R 

PROVIDER: S-EPMC10675375 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature