MiR-155 Negatively Regulates Anti-Viral Innate Responses among HIV-Infected Progressors.

ABSTRACT: HIV infection impairs host immunity, leading to progressive disease. An anti-retroviral treatment efficiently controls viremia but cannot completely restore the immune dysfunction in HIV-infected individuals. Both host and viral factors determine the rate of disease progression. Among the host factors, innate immunity plays a critical role; however, the mechanism(s) associated with dysfunctional innate responses are poorly understood among HIV disease progressors, which was investigated here. The gene expression profiles of TLRs and innate cytokines in HIV-infected (LTNPs and progressors) and HIV-uninfected individuals were examined. Since the progressors showed a dysregulated TLR-mediated innate response, we investigated the role of TLR agonists in restoring the innate functions of the pr

SUBMITTER: Pawar P 

PROVIDER: S-EPMC10675553 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature