Dataset Information

Trace Level Analysis of Per- and Polyfluorinated Substances in Fish from Various Regions in Switzerland.

ABSTRACT: Per- and polyfluorinated substances (PFASs) are persistent man-made chemicals which can end up in the food chain. In this study, the concentrations of 15 PFASs in various wild fish species from different regions in Switzerland were determined excluding hot spots of contamination. After clean-up with SPE, the samples were analyzed by HPLC-MS/MS. PFASs were detected in all but 1 of the 83 fish samples (0.07 to 40.7 µg/kg fish muscle meat). The most abundant compound in fish from subalpine lakes was perfluorooctane sulfonic acid (PFOS), comprising more than 80% of the total contamination while perfluorononanoic (PFNA), -decanoic (PFDA) and -undecanoic (PFUnDA) acid dominated in high alpine fish. PFAS levels were more elevated in subalpine lakes (median PFASs 11.1-19.0 µg/kg) than in the high alpine Lake Sils (median PFASs 0.66-2.67 µg/kg) or streams and canals in Valais (median PFASs 0.56 µg/kg). Our results indicate that wild fish may be one of the PFAS sources in human diet.

SUBMITTER: Jaus A

PROVIDER: S-EPMC10675579 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Trace Level Analysis of Per- and Polyfluorinated Substances in Fish from Various Regions in Switzerland.

Jaus Alexandra A Rhyn Peter P Valentini Judit J

Toxics 20231107 11

Per- and polyfluorinated substances (PFASs) are persistent man-made chemicals which can end up in the food chain. In this study, the concentrations of 15 PFASs in various wild fish species from different regions in Switzerland were determined excluding hot spots of contamination. After clean-up with SPE, the samples were analyzed by HPLC-MS/MS. PFASs were detected in all but 1 of the 83 fish samples (0.07 to 40.7 µg/kg fish muscle meat). The most abundant compound in fish from subalpine lakes wa ...[more]

PMID: 37999561

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Project description:Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that are chemically stable, resistant to degradation, and persistent in terrestrial and aquatic environments. Widespread use of PFAS in industrial processing and manufacturing over the last 70 years has led to global contamination of built and natural environments. The brain is a lipid rich and highly vascularized organ composed of long-lived neurons and glial cells that are especially vulnerable to the impacts of persistent and lipophilic toxicants. Generally, PFAS partition to protein-rich tissues of the body, primarily the liver and blood, but are also detected in the brains of humans, wildlife, and laboratory animals. Here we review factors impacting the absorption, distribution, and accumulation of PFAS in the brain, and currently available evidence for neurotoxic impacts defined by disruption of neurochemical, neurophysiological, and behavioral endpoints. Emphasis is placed on the neurotoxic potential of exposures during critical periods of development and in sensitive populations, and factors that may exacerbate neurotoxicity of PFAS. While limitations and inconsistencies across studies exist, the available body of evidence suggests that the neurobehavioral impacts of long-chain PFAS exposures during development are more pronounced than impacts resulting from exposure during adulthood. There is a paucity of experimental studies evaluating neurobehavioral and molecular mechanisms of short-chain PFAS, and even greater data gaps in the analysis of neurotoxicity for PFAS outside of the perfluoroalkyl acids. Whereas most experimental studies were focused on acute and subchronic impacts resulting from high dose exposures to a single PFAS congener, more realistic exposures for humans and wildlife are mixtures exposures that are relatively chronic and low dose in nature. Our evaluation of the available human epidemiological, experimental, and wildlife data also indicates heightened accumulation of perfluoroalkyl acids in the brain after environmental exposure, in comparison to the experimental studies. These findings highlight the need for additional experimental analysis of neurodevelopmental impacts of environmentally relevant concentrations and complex mixtures of PFAS.

Project description:BackgroundDespite their large numbers and widespread use, very little is known about the extent to which per- and polyfluoroalkyl substances (PFAS) can cross the placenta and expose the developing fetus.ObjectiveThe aim of our study is to develop a computational approach that can be used to evaluate the of extend to which small molecules, and in particular PFAS, can cross to cross the placenta and partition to cord blood.MethodsWe collected experimental values of the concentration ratio between cord and maternal blood (RCM) for 260 chemical compounds and calculated their physicochemical descriptors using the cheminformatics package Mordred. We used the compiled database to, train and test an artificial neural network (ANN). And then applied the best performing model to predict RCM for a large dataset of PFAS chemicals (n = 7982). We, finally, examined the calculated physicochemical descriptors of the chemicals to identify which properties correlated significantly with RCM.ResultsWe determined that 7855 compounds were within the applicability domain and 127 compounds are outside the applicability domain of our model. Our predictions of RCM for PFAS suggested that 3623 compounds had a log RCM > 0 indicating preferable partitioning to cord blood. Some examples of these compounds were bisphenol AF, 2,2-bis(4-aminophenyl)hexafluoropropane, and nonafluoro-tert-butyl 3-methylbutyrate.SignificanceThese observations have important public health implications as many PFAS have been shown to interfere with fetal development. In addition, as these compounds are highly persistent and many of them can readily cross the placenta, they are expected to remain in the population for a long time as they are being passed from parent to offspring.ImpactUnderstanding the behavior of chemicals in the human body during pregnancy is critical in preventing harmful exposures during critical periods of development. Many chemicals can cross the placenta and expose the fetus, however, the mechanism by which this transport occurs is not well understood. In our study, we developed a machine learning model that describes the transplacental transfer of chemicals as a function of their physicochemical properties. The model was then used to make predictions for a set of 7982 per- and polyfluorinated alkyl substances that are listed on EPA's CompTox Chemicals Dashboard. The model can be applied to make predictions for other chemical categories of interest, such as plasticizers and pesticides. Accurate predictions of RCM can help scientists and regulators to prioritize chemicals that have the potential to cause harm by exposing the fetus.

Dataset Information

Trace Level Analysis of Per- and Polyfluorinated Substances in Fish from Various Regions in Switzerland.

Publications

Trace Level Analysis of Per- and Polyfluorinated Substances in Fish from Various Regions in Switzerland.

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