Cleomin Exerts Acute Antinociceptive Effects in Mice via GABA_B and Muscarinic Receptors.

ABSTRACT: Cleomin, a 1,3-oxazolidine-2-thione, was recently isolated from Neocalyptrocalyx longifolium, a species traditionally used for treating painful conditions. Reports about the pharmacological activities of cleomin are lacking. Here, the antinociceptive effects of cleomin were investigated using mice models of pain, namely the formalin, the cold plate, and the tail flick tests. Motor integrity was assessed in the rota-rod test. Antagonism assays and in silico docking analyses were performed to investigate the putative mechanisms of action. Cleomin (12.5-25 mg/kg), at doses that did not induce motor impairment, induced dose-dependent antinociception in both early and late phases of the formalin test and reduced nociceptive behaviors in both the cold plate and tail flick tests. Pretreatm

SUBMITTER: Opretzka LCF 

PROVIDER: S-EPMC10675606 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature