Optofluidic Flow Cytometer with In-Plane Spherical Mirror for Signal Enhancement.

ABSTRACT: Statistical analysis of the properties of single microparticles, such as cells, bacteria or plastic slivers, has attracted increasing interest in recent years. In this regard, field flow cytometry is considered the gold standard technique, but commercially available instruments are bulky, expensive, and not suitable for use in point-of-care (PoC) testing. Microfluidic flow cytometers, on the other hand, are small, cheap and can be used for on-site analyses. However, in order to detect small particles, they require complex geometries and the aid of external optical components. To overcome these limitations, here, we present an opto-fluidic flow cytometer with an integrated 3D in-plane spherical mirror for enhanced optical signal collection. As a result, the signal-to-noise ratio is increase

SUBMITTER: Zorzi F 

PROVIDER: S-EPMC10675696 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature