Influence of Lactose Supplementation on Regulation of Streptococcus thermophilus on Gut Microbiota.

ABSTRACT: It has been found that Streptococcus thermophilus (S. thermophilus) influenced the gut microbiota and host metabolism with strain specificity in C57BL/6J mice in the previous study, though it remains unclear whether lactose as a dietary factor associated with dairy consumption is involved as the mediator in the interaction. In the present study, integrated analysis of 16S rRNA gene sequencing and untargeted metabolomics by liquid chromatography-mass spectrometry of fecal samples in C57BL/6J mice was applied to evaluate the effect of lactose on the regulation of gut microbiota by two S. thermophilus strains (4M6 and DYNDL13-4). The results showed that the influence of lactose supplementation on gut microbiota induced by S. thermophilus ingestion was strain-specif

SUBMITTER: Yu P 

PROVIDER: S-EPMC10675825 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature