The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database.

ABSTRACT:

Background

Ascorbic acid or vitamin C has antioxidant and anti-inflammatory properties that may impact markers of inflammation like C-reactive protein (CRP). However, studies specifically on vitamin C and high-sensitivity CRP (hs-CRP) have been scarce.

Methods

We conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey 2017-2018 dataset including 5,380 U.S. adults aged ≥20 years. Multiple regression models examined the relationship between plasma vitamin C and serum hs-CRP while adjusting for potential confounders. Stratified analyses and curve fitting assessed effect modification and nonlinearity.

Results

An inverse association was found between plasma vitamin C and serum hs-CRP overall (β = -0.025, 95% CI: -0.033 to -0.017, p</

SUBMITTER: Ding N 

PROVIDER: S-EPMC10675847 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature