Neutralization of extracellular histones by sodium-Β-O-methyl cellobioside sulfate in septic shock.

ABSTRACT:

Background

Extracellular histones have been associated with severity and outcome in sepsis. The aim of the present study was to assess the effects of sodium-β-O-Methyl cellobioside sulfate (mCBS), a histone-neutralizing polyanion, on the severity and outcome of sepsis in an experimental model.

Methods

This randomized placebo-controlled experimental study was performed in 24 mechanically ventilated female sheep. Sepsis was induced by fecal peritonitis. Animals were randomized to three groups: control, early treatment, and late treatment (n = 8 each). mCBS was given as a bolus (1 mg/kg) followed by a continuous infusion (1 mg/kg/h) just after sepsis induction in the early treatment group, and 4 h later in the late treatment group. Fluid administration and antimicrobial therapy

SUBMITTER: Garcia B 

PROVIDER: S-EPMC10675855 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature