RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children.

ABSTRACT:

Background

Neuroblastoma, a neuroendocrine tumor originating from the sympathetic ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many fundamental cellular processes, such as DNA replication, DNA damage repair, genomic integrity, and telomere stability. Single nucleotide polymorphisms (SNPs) in the RTEL1 gene have been reported to confer susceptibility to multiple cancers, but their contributing roles in neuroblastoma remain unclear.

Methods

We conducted a study on 402 neuroblastoma cases and 473 controls to assess the association between four RTEL1 SNPs (rs3761124 T>C, rs3848672 T>C, rs3208008 A>C and rs2297441 G>A) and neuroblastoma susceptibility.

Results

Our results show that rs3848672 T>C is significantly associated with an incr

SUBMITTER: Zhang T 

PROVIDER: S-EPMC10675872 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature