Radiogenomic analysis of cellular tumor-stroma heterogeneity as a prognostic predictor in breast cancer.

ABSTRACT:

Background

The tumor microenvironment and intercellular communication between solid tumors and the surrounding stroma play crucial roles in cancer initiation, progression, and prognosis. Radiomics provides clinically relevant information from radiological images; however, its biological implications in uncovering tumor pathophysiology driven by cellular heterogeneity between the tumor and stroma are largely unknown. We aimed to identify radiogenomic signatures of cellular tumor-stroma heterogeneity (TSH) to improve breast cancer management and prognosis analysis.

Methods

This retrospective multicohort study included five datasets. Cell subpopulations were estimated using bulk gene expression data, and the relative difference in cell subpopulations between the tumor and strom

SUBMITTER: Fan M 

PROVIDER: S-EPMC10675940 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature