Astaxanthin alleviates PM_2.5-induced cardiomyocyte injury via inhibiting ferroptosis.

ABSTRACT:

Background

Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Astaxanthin (AST), a naturally occurring red carotenoid pigment, was proved to have multiple health benefits. However, whether or not AST also exerts a protective effect on fine particulate matter (PM_2.5)-induced cardiomyocyte damage and its underlying mechanisms remain unclear.

Methods

In vitro experiments, the H9C2 cells were subjected to pretreatment with varying concentrations of AST, and then cardiomyocyte injury model induced by PM_2.5 was established. The cell viability and the ferroptosis-related proteins expression were measured in different groups. In vivo experiments, the rats were pretreated with different concentr

SUBMITTER: Ren J 

PROVIDER: S-EPMC10675963 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature