Clec7a drives gut fungus-mediated host lipid deposition.

ABSTRACT:

Background

Compared to that of bacteria, the role of gut fungi in obesity development remains unknown.

Results

Here, alterations in gut fungal biodiversity and composition were confirmed in obese pig models and high-fat diet (HFD)-fed mice. Antifungal drugs improved diet-induced obesity, while fungal reconstruction by cohousing or fecal microbiota transplantation maintained the obese phenotype in HFD-fed mice. Fungal profiling identified 5 fungal species associated with obesity. Specifically, Ascomycota_sp. and Microascaceae_sp. were reduced in obese mice and negatively correlated with fat content. Oral supplementation with fungi was sufficient to prevent and treat diet-induced obesity. Clec7a, which is involved in fungal recognition, was highly expressed in HFD-fed mice. Th

SUBMITTER: Ma J 

PROVIDER: S-EPMC10675981 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature