The credibility of subgroup analyses reported in stroke trials is low: A systematic review.

ABSTRACT:

Background

Subgroup analyses are widely used to evaluate the heterogeneity of treatment effects in randomized clinical trials. However, there is a limited investigation of the quality of prespecified and reported subgroup analyses in stroke trials. This study evaluated the credibility of subgroup analyses in stroke trials.

Methods and analysis

We searched Medline/PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the Web of Science from inception to 24 March 2021. Three reviewers screened, extracted, and analyzed the data from the publications. Primary publications of stroke trials that reported at least one subgroup effect and had published corresponding study protocols were included. The Instrument for Assessing the Credibility of Effect Modification A

SUBMITTER: Ademola A 

PROVIDER: S-EPMC10676048 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature