Large differences in collateral blood vessel abundance among individuals arise from multiple genetic variants.

ABSTRACT: Collateral blood flow varies greatly among humans for reasons that remain unclear, resulting in significant differences in ischemic tissue damage. A similarly large variation has also been found in mice that is caused by genetic background-dependent differences in the extent of collateral formation, termed collaterogenesis-a unique angiogenic process that occurs during development and determines collateral number and diameter in the adult. Previous studies have identified several quantitative trait loci (QTL) linked to this variation. However, understanding has been hampered by the use of closely related inbred strains that do not model the wide genetic variation present in the "outbred" human population. The Collaborative Cross (CC) multiparent mouse genetic reference panel was developed

SUBMITTER: Faber JE 

PROVIDER: S-EPMC10676139 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature