Ultra-low tidal volume ventilation during cardiopulmonary resuscitation shows no mitigating effect on pulmonary end-organ damage compared to standard ventilation: insights from a porcine model.

ABSTRACT:

Objective

This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitation (CPR) compared with standard ventilation (intermittent positive pressure ventilation, IPPV) can reduce pulmonary end-organ damage in the post-resuscitation period.

Methods

A prospective, randomized trial was conducted using a porcine model (n = 45). The animals were divided into three groups: IPPV, ULTVV, and a sham control group. Juvenile male pigs underwent CPR after inducing ventricular fibrillation and received the designated ventilation intervention [IPPV: tidal volume 6-8 ml per kilogram body weight (ml/kg BW), respiratory rate 10/min, FiO₂ 1.0; ULTVV: tidal volume 2-3 ml/kg BW, respiratory rate 50/min, FiO₂ 1.0].

SUBMITTER: Mohnke K 

PROVIDER: S-EPMC10676323 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature