Diversity of cortical activity changes beyond depression during Spreading Depolarizations.

ABSTRACT: Spreading depolarizations (SDs) are classically thought to be associated with spreading depression of cortical activity. Here, we found that SDs in patients with subarachnoid hemorrhage produce variable, ranging from depression to booming, changes in electrocorticographic activity, especially in the delta frequency band. In rats, depression of activity was characteristic of high-potassium-induced full SDs, whereas partial superficial SDs caused either little change or a boom of activity at the cortical vertex, supported by volume conduction of signals from spared delta generators in the deep cortical layers. Partial SDs also caused moderate neuronal depolarization and sustained excitation, organized in gamma oscillations in a narrow sub-SD zone. Thus, our study challenges the concept of ho

SUBMITTER: Nasretdinov A 

PROVIDER: S-EPMC10676372 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature