Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers.

ABSTRACT:

Aims

Apart from cardiotoxicity, the chemotherapeutic doxorubicin (DOX) induces vascular toxicity, represented by arterial stiffness and endothelial dysfunction. Both parameters are of interest for cardiovascular risk stratification as they are independent predictors of future cardiovascular events in the general population. However, the time course of DOX-induced cardiovascular toxicity remains unclear. Moreover, current biomarkers for cardiovascular toxicity prove insufficient. Here, we longitudinally evaluated functional and molecular markers of DOX-induced cardiovascular toxicity in a murine model. Molecular markers were further validated in patient plasma.

Methods and results

DOX (4 mg/kg) or saline (vehicle) was administered intra-peritoneally to young, male mice weekly

SUBMITTER: Bosman M 

PROVIDER: S-EPMC10676457 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature