Modified RNAs and predictions with the ViennaRNA Package.

ABSTRACT:

Motivation

In living organisms, many RNA molecules are modified post-transcriptionally. This turns the widely known four-letter RNA alphabet ACGU into a much larger one with currently more than 300 known distinct modified bases. The roles for the majority of modified bases remain uncertain, but many are already well-known for their ability to influence the preferred structures that an RNA may adopt. In fact, tRNAs sometimes require certain modifications to fold into their cloverleaf shaped structure. However, predicting the structure of RNAs with base modifications is still difficult due to the lack of efficient algorithms that can deal with the extended sequence alphabet, as well as missing parameter sets that account for the changes in stability induced by the modified bases.

SUBMITTER: Varenyk Y 

PROVIDER: S-EPMC10676514 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature