Comparison the therapeutic effects of bone marrow CD144⁺ endothelial cells and CD146⁺ mesenchymal stem cells in POF rats.

ABSTRACT:

Introduction

Premature ovarian insufficiency (POI) is a challenging issue in terms of reproduction biology. In this study, therapeutic properties of bone marrow CD146⁺ mesenchymal stem cells (MSCs) and CD144⁺ endothelial cells (ECs) were separately investigated in rats with POI.

Methods

POI rats were classified into control POI, POI + CD146⁺ MSCs, and POI + CD144⁺ ECs groups. Enriched CD146⁺ MSCs and CD144⁺ ECs were directly injected into ovarian tissue (15 × 10⁴ cells/10 μL) in relevant groups. After 4 weeks, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E₂) levels were measured in blood samples. Ovarian tissues were collected and subjected to Hematoxylin-E

SUBMITTER: Nazdikbin Yamchi N 

PROVIDER: S-EPMC10676523 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature