LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis.

ABSTRACT:

Background

Breast cancer (BC) is a prevalent malignancy with complex etiology and varied clinical behavior. Long non-coding RNAs (lncRNAs) have emerged as key regulators in cancer progression, including BC. Among these, lncRNA TDRKH-AS1 has been implicated in several cancers, but its role in BC remains unclear.

Methods

We conducted a comprehensive investigation to elucidate the role of TDRKH-AS1 in BC. Clinical samples were collected from BC patients, and BC cell lines were cultured. Bioinformatics analysis using the starBase database was carried out to assess TDRKH-AS1 expression levels in BC tissue samples. Functional experiments, including knockdown, colony formation, CCK-8, Transwell, and wound-healing assays, were conducted to determine the role of TDRKH-AS1 in BC cell

SUBMITTER: Ding Y 

PROVIDER: S-EPMC10676586 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature