Protective role of IL-17-producing γδ T cells in a laser-induced choroidal neovascularization mouse model.

ABSTRACT:

Background

Vision loss in patients with wet/exudative age-related macular degeneration (AMD) is associated with choroidal neovascularization (CNV), and AMD is the leading cause of irreversible vision impairment in older adults. Interleukin-17A (IL-17A) is a component of the microenvironment associated with some autoimmune diseases. Previous studies have indicated that wet AMD patients have elevated serum IL-17A levels. However, the effect of IL-17A on AMD progression needs to be better understood. We aimed to investigate the role of IL-17A in a laser-induced CNV mouse model.

Methods

We established a laser-induced CNV mouse model in wild-type (WT) and IL-17A-deficient mice and then evaluated the disease severity of these mice by using fluorescence angiography. We performed en

SUBMITTER: Chang YH 

PROVIDER: S-EPMC10676594 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature