Characteristics of circulating immune cells in HBV-related acute-on-chronic liver failure following artificial liver treatment.

ABSTRACT:

Background and aim

Liver failure, which is predominantly caused by hepatitis B (HBV) can be improved by an artificial liver support system (ALSS). This study investigated the phenotypic heterogeneity of immunocytes in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) before and after ALSS therapy.

Methods

A total of 22 patients with HBV-ACLF who received ALSS therapy were included in the study. Patients with Grade I according to the ACLF Research Consortium score were considered to have improved. Demographic and laboratory data were collected and analyzed during hospitalization. Immunological features of peripheral blood in the patients before and after ALSS were detected by mass cytometry analyses.

Results

In total, 12 patients improved and 10 patie

SUBMITTER: Ju T 

PROVIDER: S-EPMC10676598 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature