Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases.

ABSTRACT:

Background

Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing analysis of a series of metachronous colorectal cancer liver metastases (mCLM) and matched non-malignant liver tissues to investigate the genomic profile of mCLM and explore associations with the patients' prognosis and therapeutic modalities.

Methods

DNA samples from mCLM and non-malignant liver tissue pairs (n = 41) were sequenced using whole exome target enrichment and their germline and somatic genetic variability, copy number variations, and mutational signatures were assessed for associations with relapse-free (RFS) and overall survival (OS).

Results

Our genetic analysis could stratify all patients into existing targe

SUBMITTER: Heczko L 

PROVIDER: S-EPMC10676609 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature