Elevated Brain-Derived Neurotrophic Factor Levels During Depressive Mixed States.

ABSTRACT:

Objective

Neurotrophin-like brain-derived neurotrophic factor (BDNF) and pro-inflammatory cytokines may modulate the pathophysiology of mood disorders. Although several studies show alterations in these biomarkers during the depressive, manic, and euthymic states of mood disorders, evidence is lacking for those in a mixed state. Therefore, this study aimed to investigate the relationship between the depressive mixed state (DMX) and peripheral neurobiological factors.

Methods

We enrolled 136 patients with major depressive episodes. Depressive symptoms were assessed using the Quick Inventory of Depressive Symptomatology Self-Report Japanese version (QIDS-SR-J). The severity of DMX was assessed using the self-administered 12-item questionnaire (DMX-12). Categorical screening as

SUBMITTER: Otsuka N 

PROVIDER: S-EPMC10678153 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature