Impact of maternal cardiometabolic status after bariatric surgery on the association between telomere length and adiposity in offspring.

ABSTRACT: The impact of bariatric surgery on metabolic and inflammatory status are reflected in the epigenetic profile and telomere length mediated by the changes in the metabolic status of the patients. This study compared the telomere length of children born before versus after maternal bariatric surgery as a surrogate to test the influence of the mother's metabolic status on children's telomere length. DNA methylation telomere length (DNAmTL) was estimated from Methylation-EPIC BeadChip array data from a total of 24 children born before and after maternal bariatric surgery in the greater Quebec City area. DNAmTL was inversely associated with chronological age in children (r = - 0.80, p < 0.001) and significant differences were observed on age-adjusted DNAmTL between children born before versus af

SUBMITTER: San-Cristobal R 

PROVIDER: S-EPMC10679094 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature