Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75^NTR.

ABSTRACT:

Introduction

Axonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration. ProNGF is neurotrophic in the presence of its receptor tropomyosin-related kinase A (TrkA) but induces apoptosis via the pan-neurotrophin receptor (p75^NTR) when TrkA is absent. It is well established that TrkA is lost while p75^NTR is maintained in aged BFCNs, but whether aging differentially affects transport of proNGF via each receptor is unknown. Nitrative stress increases during aging, but whether age-induced nitrative stress differentially affects proNGF transport via TrkA versus p75^NTR has not yet been studied. Answering these questions is essential for developing an accu

SUBMITTER: Kropf E 

PROVIDER: S-EPMC10679388 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature