High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities.

ABSTRACT:

Introduction

Pediatric obesity has steadily increased in recent decades. Large-scale genome-wide association studies (GWAS) conducted primarily in Eurocentric adult populations have identified approximately 100 loci that predispose to obesity and type II diabetes. GWAS in children and individuals of non-European descent, both disproportionately affected by obesity, are fewer. Rare syndromic and monogenic obesities account for only a small portion of childhood obesity, so understanding the role of other genetic variants and their combinations in heritable obesities is key to developing targeted and personalized therapies. Tight and responsive regulation of the cAMP-dependent protein kinase (PKA) signaling pathway is crucial to maintaining healthy energy metabolism, and mutations in

SUBMITTER: Bloyd M 

PROVIDER: S-EPMC10679389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature