Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma.

ABSTRACT:

Introduction

Low-grade glioma (LGG) is a prevalent malignant tumor in the intracranial region. Despite the advancements in treatment methods for this malignancy over the past decade, significant challenges still persist in the form of drug resistance and tumor recurrence. The Notch signaling pathway plays essential roles in many physiological processes as well as in cancer development. However, the significance of the pathway and family genes in LGG are poorly understood.

Methods

We conducted gene expression profiling analysis using the TCGA dataset to investigate the gene set associated with the Notch signaling pathway. we have proposed a metric called "NotchScore" that quantifies the strength of the Notch signaling pathway and enables us to assess its significance in predi

SUBMITTER: Shi B 

PROVIDER: S-EPMC10679421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature