Lower cortical thickness and increased brain aging in adults with cocaine use disorder.

ABSTRACT:

Background

Cocaine use disorder (CUD) is a global health issue with severe behavioral and cognitive sequelae. While previous evidence suggests a variety of structural and age-related brain changes in CUD, the impact on both, cortical thickness and brain age measures remains unclear.

Methods

Derived from a publicly available data set (SUDMEX_CONN), 74 CUD patients and 62 matched healthy controls underwent brain MRI and behavioral-clinical assessment. We determined cortical thickness by surface-based morphometry using CAT12 and Brain Age Gap Estimate (BrainAGE) via relevance vector regression. Associations between structural brain changes and behavioral-clinical variables of patients with CUD were investigated by correlation analyses.

Results

We found significantly lowe

SUBMITTER: Schinz D 

PROVIDER: S-EPMC10679447 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature